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Chemical Structure : PF-00337210
Catalog No.: PC-60958Not For Human Use, Lab Use Only.
A potent, selective, ATP-competitive and orally bioavailable inhibitor of VEGFR-2 with Ki of 0.7 and 8.8 nM for unactivated and fully phosphorylated VEGFR-2, respectively.
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A potent, selective, ATP-competitive and orally bioavailable inhibitor of VEGFR-2 with Ki of 0.7 and 8.8 nM for unactivated and fully phosphorylated VEGFR-2, respectively; inhibits the autophosphorylation of human and murine VEGFR-2 with IC50 of 0.87 nM and 0.83 nM, respectively; is less potent against KIT (9.6 nM), CSF1-R (13 nM), PDGFR-α (11 nM) and PDGFR-β (29 nM), and does not inhibit Flt-3 (>10 uM); shows dose-dependent anti-tumor efficacy in preclinical tumor models.
Solid Tumors
Phase 1 Clinical
| M.Wt | 461.518 | |
| Formula | C26H27N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bruce JY, et al. Cancer Chemother Pharmacol. 2016 Mar;77(3):527-38.
2. Tami Marrone, et al. AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA
3. Majeti BK, et al. BMC Cancer. 2013 Apr 29;13:213.
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