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Chemical Structure : PF-03463275
Catalog No.: PC-61835Not For Human Use, Lab Use Only.
PF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM.
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PF-03463275 (PF 3463275) ia an orally bioavailable, centrally penetrant, potent, reversible, selective, and competitive inhibitor of the human GlyT1 transporter with Ki of 13 nM; shows no significant affinity for GlyT2 (Ki >1 mM); is under investigation for the treatment of schizophrenia.
Schizophrenia
Phase 2 Discontinued
| M.Wt | 376.86 | |
| Formula | C19H22ClFN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Roberts BM, et al. Neuroreport. 2010 Mar 31;21(5):390-4.
2. Liu CN, et al. Cutan Ocul Toxicol. 2014 Sep;33(3):206-11.
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