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Chemical Structure : PF-03654764
Catalog No.: PC-63033Not For Human Use, Lab Use Only.
PF-03654764 (PF 3654764) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 1.4 nM.
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PF-03654764 (PF 3654764) is a potent, selective, orally bioactive antagonist of H3 receptor with Ki of 1.4 nM; displays >1000-fold selectivity versus H1, H2, H4 and other GPCRs (IC50>10 uM); possesses optimal pharmacological and pharmacokinetic profiles, shows potential in allergen-induced nasal symptoms.
Allergy
Phase 2 Discontinued
| M.Wt | 322.454 | |
| Formula | C18H24F2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wager TT, et al. J Med Chem. 2011 Nov 10;54(21):7602-20.
2. North ML, et al. Allergy Asthma Clin Immunol. 2014 Jul 3;10(1):33.
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