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Chemical Structure : PF-04620110
CAS No.: 1109276-89-2
Catalog No.: PC-43318Not For Human Use, Lab Use Only.
PF-04620110 is a potent, selective, orally bioavailable DGAT-1 inhibitor with IC50 of 19 nM, shows no acitivity for DGAT-2 (IC50>30 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $68 | In stock | |
| 25 mg | $168 | In stock | |
| 100 mg | $598 | In stock | |
| 500 mg | Get quote |
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PF-04620110 is a potent, selective, orally bioavailable DGAT-1 inhibitor with IC50 of 19 nM, shows no acitivity for DGAT-2 (IC50>30 uM); shows high selectivity versus a broad panel of off-target pharmacologic end points; inhibits triglyceride synthesis of 3 in the intestinal-derived HT-29 cell line with IC50 of 8 nM; demonstrates in vivo DGAT-1 inhibitionthrough reduction of plasma triglyceride levels in rodent, alters the temporal and spatial pattern of dietary lipid absorption in vivo.
Diabetes
Phase 1 Discontinued
| M.Wt | 396.4397 | |
| Formula | C21H24N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Cyclohexaneacetic acid, 4-[4-(4-amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]-, trans- |
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1. Dow RL, et al. ACS Med Chem Lett. 2011 Mar 18;2(5):407-12.
2. Maciejewski BS, et al. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1;304(11):G958-69.
3. Maciejewski BS, et al. World J Gastrointest Pathophysiol. 2017 Nov 15;8(4):161-175.
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