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Chemical Structure : PF-04781340
Catalog No.: PC-61080Not For Human Use, Lab Use Only.
A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability.
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A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability; displays >150-fold selectivity over 5-HT2B receptors agonism (EC50=1484 nM); exhibits good metabolic stability in human liver microsomes (HLM) and moderate to good passive permeability in RRCK cells.
| M.Wt | 267.376 | |
| Formula | C17H21N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8.
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