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Chemical Structure : PF-04856264
CAS No.: 1235397-05-3
Catalog No.: PC-61853Not For Human Use, Lab Use Only.
PF-04856264 is a potent, selective Nav1.7 blocker with IC50 of 28 nM, dispalys >1,000-fold selectivity over Nav1.5.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PF-04856264 is a potent, selective Nav1.7 blocker with IC50 of 28 nM, dispalys >1,000-fold selectivity over Nav1.5.
PF-04856264 state-dependently and selectively inhibits Nav1.7 and significantly reduces OD1-induced spontaneous pain when delivered locally and systemically.
| M.Wt | 437.5 | |
| Formula | C20H15N5O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-cyano-4-(2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-N-(thiazol-2-yl)benzenesulfonamide |
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1. McCormack K, et al. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):E2724-32.
2. Deuis JR, et al. Toxins (Basel). 2016 Mar 17;8(3). pii: E78.
3. Deuis JR, et al. Sci Rep. 2017 Jan 20;7:40883.
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