Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PF-04859989
Catalog No.: PC-20567Not For Human Use, Lab Use Only.
PF-04859989 is a potent, selective, brain-penetrant, irreversible inhibitor of human and rat KAT II (kynurenine aminotransferase II) with IC50 of 23 and 263 nM, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PF-04859989 is a potent, selective, brain-penetrant, irreversible inhibitor of human and rat KAT II (kynurenine aminotransferase II) with IC50 of 23 and 263 nM, respectively.
PF-04859989 is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50 values of 22, 11, and >50 μM, respectively).
PF-04859989 is capable of reducing brain kynurenic acid by 50% at a dose of 10 mg/kg (sc).
| M.Wt | 178.19 | |
| Formula | C9H10N2O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Dounay AB, et al. ACS Med Chem Lett. 2012 Jan 25;3(3):187-92.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
