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Chemical Structure : PF-05198007
Catalog No.: PC-63175Not For Human Use, Lab Use Only.
PF-05198007 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 9 nM, no significant activity against Nav1.5 (IC50>10 uM).
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PF-05198007 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 9 nM, no significant activity against Nav1.5 (IC50>10 uM); increases action potential rheobase in small diameter mDRG neurons, demonstrates in vivo efficacy in a mouse capsaicin-induced neurogenic flare model.
| M.Wt | 533.901 | |
| Formula | C19H12ClF4N5O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Swain NA, et al. J Med Chem. 2017 Aug 24;60(16):7029-7042.
2. Alexandrou AJ, et al. PLoS One. 2016 Apr 6;11(4):e0152405.
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