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Chemical Structure : PF-05221304
CAS No.: 1370448-25-1
Catalog No.: PC-72388Not For Human Use, Lab Use Only.
PF-05221304 (PF 05221304) is a novel potent, selective, liver-targeted dual acetyl-CoA carboxylase (ACC1/2) inhibitor with IC50 of 13/9 nM (hACC1/2).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $388 | In stock | |
| 25 mg | $558 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PF-05221304 (Clesacostat) is a novel potent, selective, liver-targeted dual acetyl-CoA carboxylase (ACC1/2) inhibitor with IC50 of 13/9 nM (hACC1/2).
PF-05221304 displays no inhibition against a panel of e 5'-diphospho-glucuronosyltransferase (UGT) enzymes at 20 uM, as well as a broad panel of transporters, receptors, ion channels and enzymes, including the hERG channel.
PF-05221304 dose-dependently causes reductions in liver de novo lipogenesis (DNL) with a maximal reduction of 82% (EC50=5.4 nM) at 300 mg/kg (p.o.), weak DNL inhibition in lung and bone marrow.
| M.Wt | 502.571 | |
| Formula | C28H30N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoic acid |
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1. Huard K, et al. J Med Chem. 2020 Oct 8;63(19):10879-10896.
2. Calle RA, et al. Nat Med. 2021 Oct;27(10):1836-1848.
3. Ross TT, et al. Cell Mol Gastroenterol Hepatol. 2020;10(4):829-851.
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