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Chemical Structure : PF-06263276
Catalog No.: PC-60312Not For Human Use, Lab Use Only.
PF-06263276 (PF06263276, PF 6263276) is a potent, selective pan JAK inhibitor with IC50 of 2.2, 23.1, 59.9 and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
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PF-06263276 (PF06263276, PF 6263276) is a potent, selective pan JAK inhibitor with IC50 of 2.2, 23.1, 59.9 and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
PF-06263276 demonstrates good JAK potency and kinase selectivity.
PF-06263276 exhibts inhibitory potency in human whole blood versus various stimulatory cytokines (IFNα, IL-23, IL-4, IL-6 and GM-CSF) with IC50 of 0.6-5.2 uM.
PF-06263276 is suitable for inhaled and topical delivery in vivo.
| M.Wt | 566.64 | |
| Formula | C31H31FN8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jones P, et al. J Med Chem. 2017 Jan 26;60(2):767-786.
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