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Chemical Structure : PF-06424439
CAS No.: 1469284-78-3
Catalog No.: PC-38095Not For Human Use, Lab Use Only.
PF-06424439 (PF06424439) is a potent, selective, orally acitve DGAT2 inhibitor with IC50 of 14 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | $958 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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PF-06424439 (PF06424439) is a potent, selective, orally acitve DGAT2 inhibitor with IC50 of 14 nM.
PF-06424439 displays no significant activity at MGAT1-3 or DGAT1.
PF-06424439 reduces triglyderide synthesis in human hepatocytes in vitro.
PF-06424439 reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model.
| M.Wt | 39.94 | |
| Formula | C22H26ClN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-(1-(2-(1-(4-chloro-1H-pyrazol-1-yl)cyclopropyl)-3H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone |
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1. Futatsugi K, et al. J Med Chem. 2015 Sep 24;58(18):7173-85.
2. Pabst B, et al. Biochemistry. 2018 Dec 26;57(51):6997-7010.
3. Takemoto K, et al. Physiol Rep. 2020 Aug;8(15):e14542.
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