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Chemical Structure : PF-06459988
Catalog No.: PC-60296Not For Human Use, Lab Use Only.
PF-06459988 (PF06459988, PF 6459988) is a potent, selective, irreversible EGFR mutants with IC50 of 13, 7, 21 and 90 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.
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PF-06459988 (PF06459988, PF 6459988) is a potent, selective, irreversible EGFR mutants with IC50 of 13, 7, 21 and 90 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively; exhibist selectivity over wild-type EGFR (IC50>5 uM); shows potential for treatment of EGFR T790M mutation in advanced NSCLC.
Lung Cancer
Phase 1 Discontinued
| M.Wt | 431.88 | |
| Formula | C19H22ClN7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cheng H, et al. J Med Chem. 2016 Mar 10;59(5):2005-24.
2. Planken S, et al. J Med Chem. 2017 Apr 13;60(7):3002-3019.
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