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Chemical Structure : PF-06747775
CAS No.: 1776112-90-3
Catalog No.: PC-60295Not For Human Use, Lab Use Only.
Mavelertinib (PF-06747775) is a potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $458 | In stock | |
| 50 mg | $1280 | In stock | |
| 100 mg | $1980 | In stock | |
| 1 g | Get quote |
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Mavelertinib (PF-06747775) is a potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.
PF-06747775 displays excellent selectivity over wild-type EGFR (IC50=307 nM), and desirable ADME properties.
PF-06747775 shows potential for treatment of EGFR T790M mutation in advanced NSCLC.
| M.Wt | 415.433 | |
| Formula | C18H22FN9O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide |
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1. Planken S, et al. J Med Chem. 2017 Apr 13;60(7):3002-3019.
2. Patel H, et al. Eur J Med Chem. 2017 May 11. pii: S0223-5234(17)30388-4.
3. Wang S, et al. J Hematol Oncol. 2016 Apr 12;9:34.
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