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Chemical Structure : PF-06761281
Catalog No.: PC-61147Not For Human Use, Lab Use Only.
A potent, selective sodium-coupled citrate transporter (NaCT or SLC13A5) with IC50 of 0.51 uM, >20-fold selectivity over NaDC1 and NaDC3.
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A potent, selective sodium-coupled citrate transporter (NaCT or SLC13A5) with IC50 of 0.51 uM, >20-fold selectivity over NaDC1 and NaDC3; demonstrates dose-dependent inhibition of radioactive [(14)C]citrate uptake in liver and kidney in vivo, reduces fasting plasma glucose concentrations with suitable in vivo pharmacokinetic profile.
| M.Wt | 283.28 | |
| Formula | C13H17NO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huard K, et al. J Med Chem. 2016 Feb 11;59(3):1165-75.
2. Rives ML, et al. Mol Pharmacol. 2016 Dec;90(6):766-774.
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