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Chemical Structure : PF-1355
CAS No.: 1435467-38-1
Catalog No.: PC-42279Not For Human Use, Lab Use Only.
PF-1355 is a potent, selective, orally active Myeloperoxidase (MPO) inhibitor with EC50 of 1.47 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PF-1355 is a potent, selective, orally active Myeloperoxidase (MPO) inhibitor with EC50 of 1.47 uM.
PF-1355 shows high selectivity over the closely related and clinically relevant thyroid peroxidase enzyme.
PF-1355 inhibits MPO activity in LPS-treated human blood with EC50 of 2.03 uM, blocks HOCl formation in biochemical and cellular assays.
PF-1355 completely blocks kidney injury acutely and prevented any progressive diseasw in anti-GBM glomerulonephritis.
| M.Wt | 321.3516 | |
| Formula | C14H15N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 8.75 mg/mL |
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| Chemical Name/SMILES |
1(2H)-Pyrimidineacetamide, 6-(2,5-dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo- |
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1. Zheng W, et al. J Pharmacol Exp Ther. 2015 May;353(2):288-98.
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