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Chemical Structure : PF-184563
Catalog No.: PC-21617Not For Human Use, Lab Use Only.
PF-184563 is a potent and selective vasopressin V1a antagonist with IC50 of 6.7 nM (hV1a).
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PF-184563 is a potent and selective vasopressin V1a antagonist with IC50 of 6.7 nM (hV1a).
PF-184563 shows little binding to V1b or OT receptors (>10 μM).
PF-184563 dsiplays no significant inhibition of Cytochrome P450 (IC50 values >30 μM for CYP 1A2, 2C9, 2C19, 2D6 and 3A4) or blockade of the hERG channel.
PF-184563 shows weak binding hV2 receptor (IC50=8490 nM).
| M.Wt | 394.91 | |
| Formula | C21H23ClN6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Johnson PS, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5684-7.
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