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Chemical Structure : PF-431396
CAS No.: 717906-29-1
Catalog No.: PC-62800Not For Human Use, Lab Use Only.
PF-431396 is a highly potent, dual PYK2/FAK inhibitor with IC50 of 11 and 2 nM, respectively, promotes osteogenesis of hMSC cultures.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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PF-431396 is a highly potent, dual PYK2/FAK inhibitor with IC50 of 11 and 2 nM, respectively, promotes osteogenesis of hMSC cultures.
| M.Wt | 506.504 | |
| Formula | C22H21F3N6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methylmethanesulfonamide |
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1. Han S, et al. J Biol Chem. 2009 May 8;284(19):13193-201.
2. Tse KW, et al. J Biol Chem. 2009 Aug 21;284(34):22865-77.
3. Mills RD, et al. J Biol Chem. 2015 Apr 3;290(14):8677-92.
4. Kanteti R, et al. Cancer Biol Ther. 2018 Jan 5:1-12.
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