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Chemical Structure : PF-4950834
CAS No.: 1256264-62-6
Catalog No.: PC-60681Not For Human Use, Lab Use Only.
PF-4950834 is a potent, selective, ATP-competitive and orally acitve Rho kinase (ROCK) inhibitor with IC50 of 33.1 and 8.5 nM for ROCK1 and ROCK2, respectively.
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|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $558 | In stock | |
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PF-4950834 is a potent, selective, ATP-competitive and orally acitve Rho kinase (ROCK) inhibitor with IC50 of 33.1 and 8.5 nM for ROCK1 and ROCK2, respectively.
PF-4950834 displays 5-140-fold selectivity over other AGC kinase family.
PF-4950834 inhibits Jurkat T cell migration with IC50 of 68.4 nM, suppresses activation of both LPA- and thrombin-mediated activation of Rho kinase, and blocked both LPA-induced and thrombin-induced expression of ICAM-1 and VCAM-1 in HUVECs.
PF-4950834 attenuates leukocyte migration in vivo.
| M.Wt | 345.402 | |
| Formula | C21H19N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-methyl-3-{[(4-pyridin-4-ylbenzoyl)amino]methyl}benzamide |
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1. Rajagopalan LE, et al. J Pharmacol Exp Ther. 2010 Jun;333(3):707-16.
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