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Chemical Structure : PF-7006
Catalog No.: PC-21557Not For Human Use, Lab Use Only.
PF-7006 is a potent, highly-selective Mps1 (TTK) inhibitor with Ki of 0.27 nM, potently inhibit Mps1 in MDA-MB-468 tumor cells with IC50 of 2.5 nM.
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PF-7006 is a potent, highly-selective Mps1 (TTK) inhibitor with Ki of 0.27 nM, potently inhibit Mps1 in MDA-MB-468 tumor cells with IC50 of 2.5 nM.
PF-7006 triggers signaling events consistent with mitotic checkpoint abrogation.
PF-7006 at 25 mg/kg inhibited tuomor growth in the HCC1806 triple-negative breast cancer model.
PF-7006 inhibitor-induced cytotoxicity as function of retinoblastoma tumor suppressor protein (Rb1) status in tHMEC cultures co-treated with the CDK4/6 inhibitor palabociclib.
PF-7006 is shown to be selectively cytotoxic to Rb1-deficient cells relative to Rb1-competent cells.
| M.Wt | 434.50 | |
| Formula | C22H26N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ricardo Martinez, et al. PLoS One. 2015 Sep 23;10(9):e0138616.
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