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Chemical Structure : PF-719 dihydrochloride
Catalog No.: PC-62802Not For Human Use, Lab Use Only.
PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM).
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PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM).
PF-719 does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM).
PF-719 selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells.
PF-719 reduces chemoattractant-induced migration of B-2 and MZ B cells.
| M.Wt | 521.41 | |
| Formula | C22H29Cl2F3N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tse KW, et al. Cell Immunol. 2012 Jan-Feb;275(1-2):47-54.
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