PFM046 | LXR antagonist | Probechem Biochemicals

Chemical Structure : PFM046

PFM046 (PFM-046)

Catalog No.: PC-23680Not For Human Use, Lab Use Only.

PFM046 is a potent antagonist of liver X receptors (LXRs) with IC50 of 2.04 μM for LXRα and 1.58 μM for LXRβ.

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Biological Activity

PFM046 is a potent antagonist of liver X receptors (LXRs) with IC50 of 2.04 μM for LXRα and 1.58 μM for LXRβ.
PFM046 does not induce SREBP-1c activation and inhibited the activation of SCD1 and FASN.
PFM046 is able to significantly increase the expression of ABCA1 gene.
PFM046 shows a remarkable antitumor activity in two both in vitro-and in-vivo mouse models.

Physicochemical Properties

M.Wt	422.65
Formula	C29H42O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	22(S)-23-phenyl-24-norchol-5-en-3beta,22-diol

References

1. Lorenzo Pontini, et al. Eur J Med Chem. 2025 Feb 5:283:117136.

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PFM046 (PFM-046)

Biological Activity

Physicochemical Properties

References

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