Chemical Structure : PHB1 inhibitor TD6
CAS No.:
1044792-78-0
PHB1 inhibitor TD6
Catalog No.: PC-27301Not For Human Use, Lab Use Only.
PHB1 inhibitor TD6 is a highly potent and selective small-molecule inhibitor of Prohibitin 1 (PHB1), exerts potent anti-tumor activities against CRC, effectively suppresses tumor growth and dissemination by disrupting mitochondrial energy metabolism.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PHB1 inhibitor TD6 is a highly potent and selective small-molecule inhibitor of Prohibitin 1 (PHB1), exerts potent anti-tumor activities against CRC, effectively suppresses tumor growth and dissemination by disrupting mitochondrial energy metabolism.
TD6 (5-10 uM) potently suppresses CRC cell migratory capacity.
TD6 impairs mitochondrial complex I (MCI) stability by disrupting the PHB-NDUFS1 interaction, markedly reduces the protein level of NDUFS1 preferentially via lysosomal degradation rather than proteasomal pathways.
TD6 (40 mg/kg) induces tumor suppression in CT26-drived CRPM mice.
TD6 increased phosphorylation of AMPKα at Thr172 and ACC at Ser80 in T84 and HCT116 cells, suggesting activation of AMPK signaling.
TD6 inhibits mitochondrial OXPHOS in CRC cells, impairs MCI activity and ATP production.
Physicochemical Properties
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M.Wt
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545.70
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Formula
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C30H35N5O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((N-(2-(dimethylamino)ethyl)-4-methylphenyl)sulfonamido)-N-(1-(3,4-dimethylphenyl)-4-phenyl-1H-imidazol-2-yl)acetamide
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References
1. Wang K, et al. Redox Biol. 2026 Jul 8;95:104291.
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