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Chemical Structure : PHPS1 sodium
CAS No.: 1177131-02-0
Catalog No.: PC-20341Not For Human Use, Lab Use Only.
PHPS1 sodium is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PHPS1 sodium is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM.
PHPS1 displays 8- and 15-fold selectivity against most closely related PTPs, PTP1B, and Shp1.
PHPS1 (5 μM) inhibits HGF/SF-induced scattering and branching morphogenesis of MDCK epithelial cells.
PHPS1 inhibits Shp2-dependent signaling pathways, inhibits Erk1/2 but not Akt and Stat3 phosphorylation in a dose-dependent manner in MDCK cells.
PHPS1 effectively inhibits anchorage-independent growth of human tumor cells, which correlates strongly with their tumorigenicity and invasiveness.
| M.Wt | 487.42 | |
| Formula | C21H14N5NaO6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzenesulfonic acid, 4-[(1E)-2-[4,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-4-yl]diazenyl]-, sodium salt (1:1) |
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1. Klaus Hellmuth, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7275-80.
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