You are here:Home-Chemical Inhibitors & Agonists-PI3K/Akt/mTOR Pathway-PIKfyve-PIKfyve inhibitor 17
PIKfyve inhibitor 17

Chemical Structure : PIKfyve inhibitor 17

CAS No.: 2857982-26-2

PIKfyve inhibitor 17

Catalog No.: PC-49344Not For Human Use, Lab Use Only.

PIKfyve inhibitor 17 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) with IC50 of 4.0 nM, disrupts multiple phases of the lifecycle of β-coronaviruses (viral replication and viral entry).

Packing Price Stock Quantity
100 mg Get quote
250 mg Get quote
500 mg Get quote
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PIKfyve inhibitor 17 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) with IC50 of 4.0 nM, disrupts multiple phases of the lifecycle of β-coronaviruses (viral replication and viral entry).
PIKfyve inhibitor 17 displays efficacious inhibition of viral replication in the MHV-nLuc assay with IC50 of 23.5 nM.
PIKfyve inhibitor 17 potently inhibits SARS-CoV-2 replication with IC50 of 19.5 nM in a SARS-CoV-2-nLuc assay in human epithelial A549-ACE2 cells, outperformed remdesivir.
PIKfyve inhibitor 17 reduces uptake of His6-SARS-CoV-2 spike protein by HEK293T-ACE2 cells, inhibits uptake of lentivirus pseudotyped with the SARS-CoV-2 spike glycoprotein and impacts lysosomal homeostasis.s

Physicochemical Properties

M.Wt 331.423
Formula C20H21N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

11-(3-(Dimethylamino)prop-1-yn-1-yl)-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2-amine

References

1. David H. et al. Journal of Medicinal Chemistry 2022

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: