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Chemical Structure : PIN1 inhibitor VS10
Catalog No.: PC-36053Not For Human Use, Lab Use Only.
PIN1 inhibitor VS10 is a novel potent small molecule inhibitor of PIN1 (peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1), inhibits human PIN1 isomerization with IC50 of 13.4 uM.
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PIN1 inhibitor VS10 is a novel potent small molecule inhibitor of PIN1 (peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1), inhibits human PIN1 isomerization with IC50 of 13.4 uM.
VS10 displays >2-fold more potency than ATRA; reduces cancer cell viability of ovarian cancer cell lines with IC50 of 53.9-76.4 uM.
VS10 targets PIN1 to the proteasome, and induces PIN1 protein degradation in NIH3T3 fibroblasts, also shows inhibitory effects on PIN1 target proteins (cyclin D1, pSer473-Akt and β-catenin) in the OVCAR3 cell line.
| M.Wt | 377.414 | |
| Formula | C21H15NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Russo Spena C, et al. J Cell Physiol. 2019 Jan 29. doi: 10.1002/jcp.28224.
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