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PINAD-1

Chemical Structure : PINAD-1

CAS No.: 3127235-94-0

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PINAD-1 (PINAD 1, PINAD1)

Catalog No.: PC-28723Not For Human Use, Lab Use Only.

PINAD-1 is a first-in-class small molecule that selectively induces the degradation of MALAT1 with Kd of 2.5 uM, achieving an 85% reduction in MALAT1 transcript levels at 5 uM on MCF-7 cells, induces specific cleavage of the MALAT1 transcript in vitro and in cellulo.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PINAD-1 is a first-in-class small molecule that selectively induces the degradation of MALAT1 with Kd of 2.5 uM, achieving an 85% reduction in MALAT1 transcript levels at 5 uM on MCF-7 cells, induces specific cleavage of the MALAT1 transcript in vitro and in cellulo.

Physicochemical Properties

M.Wt 832.02
Formula C43H61N9O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(1-(17-(2-((dimethylamino)methyl)-1H-imidazol-1-yl)-3,6,9,12,15-pentaoxaheptadecyl)-1H-1,2,3-triazol-4-yl)-N-(3-methoxybenzyl)-N-(5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-yl)butanamide

References

1. Brega CAT, et al. Chemistry. 2026 Apr 22;32(15):e00025.

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