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Chemical Structure : PIP-199
Catalog No.: PC-21028Not For Human Use, Lab Use Only.
PIP-199 is a small-molecule inhibitor of the Fanconi anemia complementation group M-RecQ-mediated genome instability protein (FANCM-RMI) protein-protein interaction, inhibits RMI core complex with Kd of 3.4 uM.
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PIP-199 is a small-molecule inhibitor of the Fanconi anemia complementation group M-RecQ-mediated genome instability protein (FANCM-RMI) protein-protein interaction, inhibits RMI core complex with Kd of 3.4 uM.
PIP-199 exhibits selective inhibition of the RMI core complex/MM2 complex formation with IC50 of 36 uM.
PIP-199 similarly phenocopies FANCM depletion.
| M.Wt | 456.55 | |
| Formula | C27H28N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Andrew F Voter, et al. J Biomol Screen. 2016 Jul;21(6):626-33.
2. Xinyi Wu, et al. J Med Chem. 2023 Aug 9. doi: 10.1021/acs.jmedchem.3c00674.
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