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Chemical Structure : PITPNM3 inhibitor C8018-7840
Catalog No.: PC-49405Not For Human Use, Lab Use Only.
PITPNM3 inhibitor C8018-7840 is a selective small molecular inhibitor of oncogenic membrane-associated phosphatidylinositol transfer protein 3 (PITPNM3) with binding KD of 500 nM, inhibits CCL18-PITPNM3 signaling mediated cell migration and invasion.
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PITPNM3 inhibitor C8018-7840 is a selective small molecular inhibitor of oncogenic membrane-associated phosphatidylinositol transfer protein 3 (PITPNM3) with binding KD of 500 nM, inhibits CCL18-PITPNM3 signaling mediated cell migration and invasion.
C8018-7840 inhibited PITPNM3-induced cell migration as well as invasion in a concentration-dependent manner in MDA-MB-231 and MCF-7 cells, notably decreased CCL18-PITPNM3 induced vimentin and recovered CDH1 expression.
C8018-7840 loaded nanoparticles (NP-C8018- 7840) with its volume ratio to PEG-PLGA at 1:20, showed favorable pharmacokinetics for in vivo use.
C8018-7840 significantly repress metastasis of breast cancer in mouse xenograft models and organoid models.
| M.Wt | 529.593 | |
| Formula | C30H31N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zihao Liu, et al. Adv Sci (Weinh). 2022 Oct 26;e2204649.
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