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Chemical Structure : PJ-68
Catalog No.: PC-63229Not For Human Use, Lab Use Only.
PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8).
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PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8).
PJ-68 markedly decreases BCR-ABL mRNA levels in both CD34+CD38-cells and CD34+CD38+ cells, reduces survival and self-renewal capacity of CML CD34+ cells, increases p15INK4B and p27KIP1 but not p16INK4A and p57KIP2 expression.
PJ-68 reduces growth of CML LSCs and prolongs survival of CML mice.
| M.Wt | 354.497 | |
| Formula | C25H26N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jin Y, et al. J Clin Invest. 2016 Oct 3;126(10):3961-3980.
2. Kaushik S, et al. Leukemia. 2018 Feb;32(2):499-509.
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