PK11000 | Y220C p53 reactivator | Probechem Biochemicals

Chemical Structure : PK11000

CAS No.: 38275-34-2

PK11000 (PK-11000)

Catalog No.: PC-25969Not For Human Use, Lab Use Only.

PK11000 is a small molecule allosteric disruptor Y220C and Y220C p53 reactivator, reactivates p53 native function in Y220C mutant present tumors.

Packing	Price	Stock
25 mg	$88	In stock
50 mg	$128	In stock
100 mg	$198	In stock
500 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

PK11000 is a small molecule allosteric disruptor Y220C and Y220C p53 reactivator, reactivates p53 native function in Y220C mutant present tumors.
PK11000 rescues Y220C mutant p53 DBD by recapitulating WT dynamics and hydrogen-bonding network.
PK11000 restore stability and reinstate activity both in vitro and in vivo in rodent models.

Physicochemical Properties

M.Wt	236.63
Formula	C6H5ClN2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid

References

1. Han ISM, et al. ACS Omega. 2022 Jan 13;7(3):2831-2841.

2. Han ISM, et al. ACS Omega. 2024 Apr 22;9(18):19837-19847.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com

PK11000 (PK-11000)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.