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Chemical Structure : PKA inhibitor H89
CAS No.: 130964-39-5
Catalog No.: PC-20821Not For Human Use, Lab Use Only.
PKA inhibitor H89 (H-89 dihydrochloride) is a potent, selective cAMP-dependent protein kinase A (PKA) inhibitor with IC50 of 48 nM, weakly inhibits PKG, PKC, casein kinases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $168 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | $458 | In stock | |
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| 1 g | Get quote |
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PKA inhibitor H89 (H-89 dihydrochloride) is a potent, selective cAMP-dependent protein kinase A (PKA) inhibitor with IC50 of 48 nM, weakly inhibits PKG, PKC, casein kinases.
PKA inhibitor H89 causes a dose-dependent inhibition of the forskolin-induced protein phosphorylation, with no decrease in intracellular cyclic AMP levels in PC12D cells.
PKA inhibitor H89 significantly inhibits the forskolin-induced neurite outgrowth from PC12D cells.
PKA inhibitor H89 (30 μM) inhibited significantly cAMP-dependent histone IIb phosphorylation activity in cell lysates but did not affect other protein phosphorylation activity.
PKA inhibitor H89 significantly increases seizure latency and threshold in PTZ-treated animals.
| M.Wt | 519.28 | |
| Formula | C20H22BrCl2N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-N-(2-((3-(4-bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamide dihydrochloride |
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1. Hansen SH, et al. J Cell Biol. 1994 Aug;126(3):677-87.
2. Chijiwa T, et al. J Biol Chem . 1990 Mar 25;265(9):5267-72.
3. Hosseini-Zare MS, et al. Eur J Pharmacol. 2011 Nov 30;670(2-3):464-70.
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