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Chemical Structure : PNU37883A
CAS No.: 57568-80-6
Catalog No.: PC-21738Not For Human Use, Lab Use Only.
PNU37883A (PNU37883 hydrochloride) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker with IC50 of 6 uM and 15 uM for Kir6.1/SUR2B and Kir6.2/SUR2B, respectively.
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| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
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PNU37883A (PNU37883 hydrochloride) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker with IC50 of 6 uM and 15 uM for Kir6.1/SUR2B and Kir6.2/SUR2B, respectively.
PNU-37883A significantly inhibits currents generated by expressing Kir6.2Δ26 alone with IC50 of 5 uM.
PNU37883A produces a concentration-dependent attenuation of the relaxation of agmatine (100 μM) in phenylephrine- or KCl- precontracted aortic rings.
| M.Wt | 381.99 | |
| Formula | C21H36ClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-N'-(Adamantan-1-yl)-N-cyclohexylmorpholine-4-carboximidamide hydrochloride |
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1. Yi Cui, et al. Br J Pharmacol. 2003 May;139(1):122-8.
2. Guang-Yuan Mar, et al. Int J Exp Pathol. 2013 Feb;94(1):17-24.
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