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Chemical Structure : PP2Cδ (WIP1) inhibitor C23
Catalog No.: PC-49039Not For Human Use, Lab Use Only.
PP2Cδ inhibitor C23 is a potent PP2Cδ (WIP1, PPM1D) inhibitor, not only directly inhibits PP2Cδ activity but also suppresses high glucose (HG)-induced PP2Cδ expression.
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PP2Cδ inhibitor C23 is a potent PP2Cδ (WIP1, PPM1D) inhibitor, not only directly inhibits PP2Cδ activity but also suppresses high glucose (HG)-induced PP2Cδ expression.
PP2Cδ inhibitor C23 exhibits a striking cytotoxicity on MCF-7 cells with IC50 of 0.98 uM in growth inhibition assays.
C23 inhibits HG-induced cancer cell progression via PP2Cd inhibition mediated by HSP27 induction.
C23 suppresses HG-induced PP2Cδ expression, cancer cell proliferation, migration, and invasion.
C23 blocks the growth of MCF-7 xenografts in diabetic nude mice.
| M.Wt | 326.444 | |
| Formula | C19H26N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wu K, et al. Antioxid Redox Signal. 2019 Jun 10;30(17):1983-1998.
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