PRDX1 inhibitor 7e | PRDX1 inhibitor | Probechem Biochemicals

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Chemical Structure : PRDX1 inhibitor 7e

PRDX1 inhibitor 7e (PRDX1-IN-1)

Catalog No.: PC-25315Not For Human Use, Lab Use Only.

PRDX1 inhibitor 7e (PRDX1-IN-1) is a potent peroxiredoxin 1 (PRDX1) inhibitor with IC50 of 164 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PRDX1 inhibitor 7e (PRDX1-IN-1) is a potent peroxiredoxin 1 (PRDX1) inhibitor with IC50 of 164 nM.
7e inhibits the proliferation, invasion and migration of cancer cells (A549 IC50=1.92 uM).
7e suppresses the key signaling pathways (AKT and ERK) and promoted the expression of apoptosis-related proteins (cleaved caspase-3/8 and cleaved PARP) in A549 cells
7e shows considerable antitumor efficacy without obvious toxicity in vivo.

Physicochemical Properties

M.Wt	713.96
Formula	C46H55N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(9β,13α,14β,20α)-3-cinnamyl oxyl-9,13-dimethyl-2-oxo-N-(3,5,6-Trimethyl-2-pyrazinyl)methyl-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-amide

References

1. Ying Bai, et al. Eur J Med Chem. 2023, 259, 115656.

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PRDX1 inhibitor 7e (PRDX1-IN-1)

Biological Activity

Physicochemical Properties

References

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