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Chemical Structure : PRDX1 inhibitor H7
Catalog No.: PC-22248Not For Human Use, Lab Use Only.
PRDX1 inhibitor H7 is a specific small molecule inhibitor of antioxidant enzyme peroxiredoxin I (Prdx I) with IC50 of 7.85 uM, induces leukemia-cell differentiation in vitro and in vivo.
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PRDX1 inhibitor H7 is a specific small molecule inhibitor of antioxidant enzyme peroxiredoxin I (Prdx I) with IC50 of 7.85 uM, induces leukemia-cell differentiation in vitro and in vivo.
H7 directly and non-covalently binds to Prdx I but not to Prdxs II-V in cells.
Knockdown or overexpression of Prdx I increases or decreases H7-induced cell differentiation, H7 induces partial differentiation of NB4 cells.
H7 induces cell differentiation of non-APL leukemia cell lines and primary cells, through activation of the ROS-Erk1/2-C/EBPβ pathway.
H7 (10 mg/kg, 20 mg/kg, introperitoneal) daily for 5 consecutive days induced leukemia-cell differentiation in APL leukemic mice.
| M.Wt | 325.38 | |
| Formula | C18H15NO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wei Wei, et al. Oncotarget. 2016 Jan 26;7(4):3873-83.
2. Wirakiat W, et al. Life Sci. 2020 Oct 1;258:118227.
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