Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PRGL493
CAS No.: 2479378-45-3
Catalog No.: PC-38301Not For Human Use, Lab Use Only.
PRGL493 (PRGL 493) is a potent selective inhibitor of Acyl-CoA synthetase 4 (ACSL4).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PRGL493 (PRGL 493) is a potent selective inhibitor of Acyl-CoA synthetase 4 (ACSL4).
PRGL493 inhibited the proliferation of highly aggressive breast and prostate cancer cells with IC50 of 23 uM and 27 uM, respectively.
PRGL493 blocked cell proliferation and tumor growth in both breast and prostate cellular and animal models and sensitized tumor cells to chemotherapeutic and hormonal treatment.
PGRL493 inhibited de novo steroid synthesis in testis and adrenal cells, in a mouse model and in prostate tumor cells.
| M.Wt | 451.49 | |
| Formula | C25H21N7O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(4-(3-(5-methylfuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)-3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazin-2-yl)acetamide |
|
1. Ana F Castillo, et al. Cell Mol Life Sci. 2021 Mar;78(6):2893-2910.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
