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Chemical Structure : PS-1145
CAS No.: 431898-65-6
Catalog No.: PC-45398Not For Human Use, Lab Use Only.
PS-1145 (PS1145) is a specific IκB kinase (IKK) inhibitor with IC50 of 88 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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PS-1145 (PS1145) is a specific IκB kinase (IKK) inhibitor with IC50 of 88 nM.
PS-1145 shows no activity for JNK2, c-Src, p38α, IRAK, Lck, etc..
PS-1145 blocks TNFα-induced NF-κB activation in MM cells through inhibition of IκBα phosphorylation and degradation of IκBα, respectively.
PS-1145 blocks the protective effect of IL-6 against Dex-induced apotosis, inhibits both IL-6 secretion from BMSCs triggered by MM cell adhesion and proliferation of MM cells adherent to BMSCs.
| M.Wt | 322.7484 | |
| Formula | C17H11ClN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 43 mg/mL |
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| Chemical Name/SMILES |
3-Pyridinecarboxamide, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)- |
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1. Hideshima T, et al. J Biol Chem. 2002 May 10;277(19):16639-47.
2. Akiyama M, et al. Cancer Res. 2002 Jul 1;62(13):3876-82.
3. Vodanovic-Jankovic S, et al. Blood. 2006 Jan 15;107(2):827-34.
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