Chemical Structure : PSSI-51
CAS No.:
139981-15-0
PSSI-51
(Peripheral selective SCOT inhibitor-51)
Catalog No.: PC-24691Not For Human Use, Lab Use Only.
PSSI-51 is a potent, peripheral selectice succinyl-CoA:3-ketoacid-CoA transferase (SCOT) inhibitor, inhibits peripheral tissue (i.e., muscle) SCOT activity and ketone oxidation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PSSI-51 is a potent, peripheral selectice succinyl-CoA:3-ketoacid-CoA transferase (SCOT) inhibitor, inhibits peripheral tissue (i.e., muscle) SCOT activity and ketone oxidation.
PSSI-51 binds within the oxyanion binding pocket of SCOT.
PSSI-51 selectively inhibits SCOT without interacting with canonical targets of diphenylbutylpiperidines (DPBPs).
PSSI-51 inhibits ketone oxidation and improves glycemia in obese mice.
PSSI-51 exhibits minimal brain penetration and lacks the adverse effects associated with DPBPs.
Physicochemical Properties
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M.Wt
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475.54
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Formula
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C28H27F2N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(3-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)propyl)isoindoline-1,3-dione
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References
1. Tabatabaei Dakhili SA, et al. iScience. 2025 Apr 3;28(5):112336.
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