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Chemical Structure : PT-91
Catalog No.: PC-21541Not For Human Use, Lab Use Only.
PT91 is a small-molecule GPR27 (SREB1) agonist with pEC50 of 6.15 (human GPR27) in β-arrestin 2 recruitment-based firefly luciferase complementation assay, Emax=100%.
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PT91 is a small-molecule GPR27 (SREB1) agonist with pEC50 of 6.15 (human GPR27) in β-arrestin 2 recruitment-based firefly luciferase complementation assay, Emax=100%.
PT91 displays no activity against the adrenoceptor β2 (β2AR).
PT91 does not significantly influence the levels of cAMP through GPR27.
PT91 displays high metabolic stability and brain exposure in mice.
| M.Wt | 450.43 | |
| Formula | C21H17F3N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thanigaimalai Pillaiyar, et al. Journal of Medicinal Chemistry, 2023.
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