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Chemical Structure : PTC-124
CAS No.: 775304-57-9
Catalog No.: PC-21295Not For Human Use, Lab Use Only.
PTC-124 (Ataluren, PTC124) is an orally bioavailable small molecule that selectively induces ribosomal readthrough of premature but not normal termination codons.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $158 | In stock | |
| 100 mg | $258 | In stock | |
| 200 mg | $398 | In stock | |
| 1 g | Get quote |
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PTC-124 (Ataluren, PTC124) is an orally bioavailable small molecule that selectively induces ribosomal readthrough of premature but not normal termination codons.
PTC-124 (Ataluren) promotes suppression of the human CFTR-G542X nonsense allele in cystic fibrosis (CF) mouse model.
PTC-124 (Ataluren) is a potent firefly luciferase (FLuc) inhibitor with IC50 of 7 nM.
PTC-124 (Ataluren) promotes ribosomal readthrough of premature stop codons in mRNA and offers therapeutic potential for multiple genetic diseases.
| M.Wt | 284.25 | |
| Formula | C15H9FN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid |
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1. Auld DS, et al. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3585-90.
2. Du M, et al. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2064-9.
3. Welch EM, et al. Nature. 2007 May 3;447(7140):87-91.
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