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Chemical Structure : PTC725
Catalog No.: PC-62618Not For Human Use, Lab Use Only.
PTC725 is a potent, selective, and orally bioavailable inhibitor of HCV NS4B, inhibits HCV 1b (Con1) replicons with EC50 of 1.7 nM.
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PTC725 is a potent, selective, and orally bioavailable inhibitor of HCV NS4B, inhibits HCV 1b (Con1) replicons with EC50 of 1.7 nM; displays a selectivity index of >5,000 with respect to cellular GAPDH, and >1,000-fold selectivity window with respect to cytotoxicity; retains fully activity against HCV replicon mutants that are resistant to inhibitors of NS3 protease and NS5B polymerase, demonstrates synergistic affect in combination with alpha interferon in vivo.
| M.Wt | 518.491 | |
| Formula | C23H18F4N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gu Z, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3250-61.
2. Zhang N, et al. J Med Chem. 2014 Mar 13;57(5):2121-35.
3. Graci JD, et al. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7060-7066.
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