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Chemical Structure : PTI-125
CAS No.: 1224591-33-6
Catalog No.: PC-72845Not For Human Use, Lab Use Only.
PTI-125 (Simufilam, Sumifilam) is a small molecule targeting scaffolding protein filamin A (FLNA), preferentially binds altered FLNA and restores its native conformation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $228 | In stock | |
| 25 mg | $428 | In stock | |
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| 250 mg | Get quote | ||
| 1 g | Get quote |
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PTI-125 (Simufilam, Sumifilam) is a small molecule targeting scaffolding protein filamin A (FLNA), preferentially binds altered FLNA and restores its native conformation.
PTI-125 restores receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
PTI-125 reduces tau hyperphosphorylation, aggregated Aβ42 deposition, neurofibrillary tangles, and neuroinflammation in triple-transgenic (3xTg) Alzheimer's disease (AD) mice.
PTI-125 alleviates neuronal abnormalities and reduced seizure frequency in mice modeling TSC and FCDII with mutations in PI3K-ras homolog enriched in brain (Rheb) pathway genes.
| M.Wt | 259.353 | |
| Formula | C15H21N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-benzyl-8-methyl-1,4,8-triazaspiro[4.5]decan-2-one |
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1. Zhang L, et al. Sci Transl Med. 2020 Feb 19;12(531):eaay0289.
2. Wang HY, et al. Neurobiol Aging. 2017 Jul;55:99-114.
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