PTPN2/1 inhibitor WS35

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Chemical Structure : PTPN2/1 inhibitor WS35

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Catalog No.: PC-25843Not For Human Use, Lab Use Only.

PTPN2/1 inhibitor WS35 is potent dual PTPN2 (TCPTP) / PTPN1 inhibitor with IC50 of 5.8 /12.8 nM respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PTPN2/1 inhibitor WS35 is potent dual PTPN2 (TCPTP) / PTPN1 inhibitor with IC50 of 5.8 /12.8 nM respectively.
WS35 modulates the IFNγ-JAK-STAT signaling axis, significantly augmenting CD8+ T-cell tumor infiltration.
WS35 monotherapy and its combination with an anti-PD-1 antibody achieved robust tumor growth suppression, outperforming AC484, with no observable systemic toxicity in B16-OVA syngeneic models.

Physicochemical Properties

M.Wt	422.48
Formula	C19H23FN4O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2-Fluoro-6-hydroxy-4-(6-(isopentylamino)-5-methylpyridin-3-yl)phenyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxide

References

1. Dawei Wang, et al. J Med Chem. 2025 Oct 23;68(20):21917-21938.

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