Chemical Structure : PTPN22 inhibitor L-32
CAS No.:
PTPN22 inhibitor L-32
Catalog No.: PC-27250Not For Human Use, Lab Use Only.
PTPN22 inhibitor L-32 is a potent, selective PTPN22 inhibitor with IC50 of 0.49 uM and Ki of 0.28 uM, >14-fold selective over other PTPs.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PTPN22 inhibitor L-32 is a potent, selective PTPN22 inhibitor with IC50 of 0.49 uM and Ki of 0.28 uM, >14-fold selective over other PTPs.
L-32 competitively inhibits PTPN22 and makes putative interactions with multiple residues that are unique to PTPN22.
L-32 exhibits reduced inhibitory potency against the K136S, K136R, and K138A mutants (IC50=1.11-2.16 uM) relative to the wild-type enzyme.
L-32 (10 uM) increases LCK and ERK1/2 phosphorylation levels in a dose-dependent manner
L-32 efficiently enhances T cell signaling and activation, enhances α-CD28-mediated IL-2 expression and secretion from Jurkat T cells.
L-32 reduces MC38 tumor growth in MC38 tumor model in immune-competent C57BL/6J mice.
Physicochemical Properties
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M.Wt
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499.52
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Formula
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C28H25N3O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-6-(2-(4'-ethyl-3-hydroxy-[1,1'-biphenyl]-4-carboxamido)propanamido)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
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References
1. Lin J, et al. J Med Chem. 2026 Jul 2. doi: 10.1021/acs.jmedchem.5c03467.
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