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Chemical Structure : PTX-BD10-2
Catalog No.: PC-21241Not For Human Use, Lab Use Only.
PTX-BD10-2 (BD10-2) is a selective, brain-penetrant small molecule TrkB/C receptor partial agonist, shows survival-promoting activity.
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PTX-BD10-2 (BD10-2) is a selective, brain-penetrant small molecule TrkB/C receptor partial agonist, shows survival-promoting activity.
PTX-BD10-2 (BD10-2) promotes survival of 3T3-TrkB and 3T3-TrkC cells in a dose-dependent manner, but has no effect on survival of TrkA- or p75-expressing 3T3 cells.
PTX-BD10-2 (BD10-2) reverses cholinergic neuron atrophy associated with pathological tau (AT8 antibody) in late-stage APPL/S mice.
PTX-BD10-2 (BD10-2) prevents aberrant AKT, CaMKII, and GLUA1 phosphorylation, and enhances activity-dependent recruitment of synaptic proteins.
PTX-BD10-2 (BD10-2) significantly reduces memory and LTP impairments, as well as synaptic- and neurotrophin-related signaling deficits in APPL/S mice.
PTX-BD10-2 (BD10-2) also has potentially favorable effects on LTP-dependent complement pathway and synaptic gene transcription.
| M.Wt | 444.62 | |
| Formula | C26H40N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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