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Chemical Structure : PV-1019
Catalog No.: PC-60283Not For Human Use, Lab Use Only.
PV-1019 (NSC744039) is a potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.
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PV-1019 (NSC744039) is a potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.
PV-1019 displays much reduced or no activity against a panel of 52 other cellular kinases, including Chk1.
PV-1019 inhibits Chk2-mediated phosphorylation of Cdc25C (IC50=260 nM), and nd HDMX degradation in response to DNA damage.
PV-1019 protects normal mouse thymocytes against ionizing radiation-induced apoptosis.
| M.Wt | 379.38 | |
| Formula | C18H17N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jobson AG, et al. J Pharmacol Exp Ther. 2009 Dec; 331(3):816-26.
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