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Chemical Structure : PXS-4787
Catalog No.: PC-49359Not For Human Use, Lab Use Only.
PXS-4748 (PXS4748) is a potent, selective and irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 2.0 uM and 3.2/0.6/1.4/0.2 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.
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PXS-4748 (PXS4748) is a potent, selective and irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 2.0 uM and 3.2/0.6/1.4/0.2 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.
PXS-4787 dose-dependently inhibits lysyl oxidases with IC50 values ranging from 0.2 µM (LOXL4) to 3 µM (LOXL1) and displays comparable inhibitory activity across species.
PXS-4787 selectivity targets lysyl oxidases and is neither an inhibitor of, nor a substrate for, related oxidases.
PXS-4787 (0-10 uM) reduces collagen formation, deposition and crosslinking in primary human dermal fibroblasts cultured in vitro.
PXS-4748 effectively target extracellular LOX without impacting on skin cell phenotype or leading to a compensatory response.
| M.Wt | 229.269 | |
| Formula | C10H12FNO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chaudhari N, et al. Nat Commun. 2022 Sep 22;13(1):5555.
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