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Chemical Structure : PXS-5153A
CAS No.: 2125956-82-1
Catalog No.: PC-35895Not For Human Use, Lab Use Only.
PXS-5153A (PXS5153A) is a potent, selective, fast-acting, dual LOXL2/LOXL3 inhibitor with IC50 of <40 nM against all mammalian species LOXL2, inhibits human LOXL3 with IC50 of 63 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $158 | In stock | |
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PXS-5153A (PXS5153A) is a potent, selective, fast-acting, dual LOXL2/LOXL3 inhibitor with IC50 of <40 nM against all mammalian species LOXL2, inhibits human LOXL3 with IC50 of 63 nM.
PXS-5153A displays >40-fold selectivity for LOXL2 over both LOX and LOXL1 and >700-fold over other related amine oxidases.
PXS-5153A dose-dependently reduced LOXL2-mediated collagen oxidation and collagen crosslinking in vitro.
PXS-5153A reduced disease severity and improved liver function by diminishing collagen content and collagen crosslinks in carbon tetrachloride or streptozotocin/high fat diet-induced liver fibrosis models.
| M.Wt | 475.404 | |
| Formula | C20H25Cl2FN4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-3-(1-(4-amino-2-fluorobut-2-en-1-yl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)-N,N-dimethylbenzenesulfonamide dihydrochloride |
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1. Schilter H, et al. J Cell Mol Med. 2018 Dec 9. doi: 10.1111/jcmm.14074.
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