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Chemical Structure : PXS-5505 dihydrochloride monohydrate
CAS No.: 2414974-55-1
Catalog No.: PC-21385Not For Human Use, Lab Use Only.
PXS-5505 dihydrochloride monohydrate is an orally available, small-molecule, irreversible inhibitor of all lysyl oxidases (pan-LOX) family members, with potential antifibrotic activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PXS-5505 dihydrochloride monohydrate is an orally available, small-molecule, irreversible inhibitor of all lysyl oxidases (pan-LOX) family members, with potential antifibrotic activity.
PXS-5505 inhibited lysyl oxidase activity in the skin and LOXL2 activity in the lung.
PXS-5505 exhibited anti-fibrotic effects in the SSc skin mouse model, reducing dermal thickness and α-smooth muscle actin.
PXS-5505 reduced pulmonary fibrosis toward normal levels in bleomycin-induced mouse lung models.
PXS-5505 also reduced fibrotic extent in models of the ischaemia-reperfusion heart, the unilateral ureteral obstruction kidney, and the CCl4-induced fibrotic liver.
| M.Wt | 371.25 | |
| Formula | C13H17Cl2FN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-3-fluoro-4-(quinolin-8-ylsulfonyl)but-2-en-1-amine dihydrochloride hydrate |
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1. Yimin Yao, et al. Int J Mol Sci. 2022 May 16;23(10):5533.
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