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Chemical Structure : PXS-6302
CAS No.: 2584947-54-4
Catalog No.: PC-49358Not For Human Use, Lab Use Only.
PXS-6302 (PXS6302) is a potent, irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 3.7 uM and 3.4/0.4/1.5/0.3 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.
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PXS-6302 (PXS6302) is a potent, irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 3.7 uM and 3.4/0.4/1.5/0.3 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively.
PXS-6302 is a more selective inhibitor than β-aminoproprionitrile (BAPN) and is also optimally designed for topical application.
Topical application of PXS-6302 (1.5% PXS-6302 oil in water cream) reduces skin fibrosis in repeat dose bleomycin-induced skin fibrosis in mice.
Topical application of PXS-6302 (1.5% PXS-6302 oil in water cream) reduces collagen deposition and crosslinking in a murine model of excision injury.
Topical application of PXS-6302 (3% PXS-6302 oil in water cream) improves scar appearance with no reduction in tissue strength in porcine models of excision and burn injury.
| M.Wt | 265.250 | |
| Formula | C10H10F3NO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-3,4,4-trifluoro-4-(phenylsulfonyl)but-2-en-1-amine |
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1. Nutan Chaudhari, et al. Nat Commun. 2022 Sep 22;13(1):5555.
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